Regular ArticleStatistical Parametric Mapping of Regional Glucose Metabolism in Mesial Temporal Lobe Epilepsy
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2018, Revue NeurologiqueCitation Excerpt :Some studies have analyzed interhemispheric asymmetries, such as left to right subtraction or the asymmetry index, and demonstrated improvement of preoperative evaluations for TLEs. In most of these studies, interhemispheric asymmetry was calculated from the mean region-of-interest (ROI) value or volume of interest (VOI) [111,112], whereas other studies applied asymmetry to voxel-based quantitative analysis (Fig. 4) [113], an invaluable tool for detecting subsequent epileptic networks by voxel-to-voxel comparisons of two PET datasets [60]. In a study of 41 patients with epilepsy, Van’t Klooster et al. [108] showed that, although detection sensitivity was similar between visual assessment and quantitative analysis, the latter detected four out of five initially negative visually assessed scans.