CommunicationsUse of 99mTc-Labeled Triethylenetetramine–Polystyrene Resin for Measuring the Gastric Emptying Rate in Humans
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2017, International Journal of PharmaceuticsCitation Excerpt :Techniques previously used by physiologists include gastric intubation to sample dye dilution, sampling of gastric meal volumes (recoverable after different periods; Hunt, 1963), or the movement of radio-opaque markers using X-rays. The principle of incorporating gamma-emitting radiopharmaceuticals into a food matrix or a formulation allowed the non-invasive visualization of the ligand with a much reduced dose compared to X-rays and less interference with normal function (Digenis et al., 1977). Studies of GE using scintigraphic techniques with radiolabeled standard meals were introduced by Griffith and colleagues in 1966 (Griffith et al., 1966) and further refined in the seventies with the introduction of simultaneous measurement of GE of both solids and liquids in 1976 (Heading et al., 1976).
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We thank Ms. S. Yonts for assistance and Dr. F. DeLand for guidance and encouragement.