Patient Characteristics
| Characteristic | Patient 1 | Patient 2 | Patient 3 |
|---|---|---|---|
| Age | 23 mo | 6 y | 3.5 y |
| Sex | Male | Female | Female |
| Clinical presentation | Ataxia, irritability, progressing to paraparesis | Limp, discomfort on left side of abdomen | Body pain, swelling of left eye, weight loss, cachexia |
| Histopathology | Poorly differentiated neuroblastoma | Poorly differentiated neuroblastoma | Not done |
| Cytogenetics | Not done | ||
| N-Myc | Not amplified | Not amplified | |
| SCA (1p−, 11q+, any other, LOH) | Not seen | 1q+, 11q−, 17q+, X−, no LOH | |
| Alk | No rearrangement | No rearrangement | |
| NCA | Not seen | Not seen | |
| Bone marrow | No evidence of infiltration | Infiltrated by nonhematopoietic tumor, neuroblastoma | Infiltrated by nonhematopoietic tumor, neuroblastoma |
| Urinary catecholamines | |||
| VMA/creatinine ratio | 14.1 (0–6.3) | 90.7 (0–4.7) | 209.8 (0–6.3) |
| HVA/creatinine ratio | 9.9 (0–13.6) | 95.6 (0–9.4) | 191.0 (0–13.6) |
SCA = segmental chromosomal abnormalities; LOH = loss of heterozygosity; NCA = numerical chromosomal abnormalities; 1p− = 1 p deletion; 11q− = 11q deletion; 17q+ = gain of 17q; X− = deletion of X-chromosome; N-Myc = N-Myc oncogene; Alk = anaplastic lymphoma kinase; VMA = vanillylmandelic acid; HVA = homovanillic acid.
Data in parentheses represent reference range.