Diagnostic Performance of 18F-Fluoroestradiol PET Versus Immunohistochemistry in 12 Studies
| Definition of ER+ | |||||
| Study | n | Sensitivity | Specificity | IHC | PET |
| Peterson (31) | |||||
| Nonbreast | 10 | 0.99 (0.67–1) | 0.96 (0.33–1) | Allred score > 2 | SUVmean > 1.5 |
| Breast | 4 | 0.98 (0.50–1) | Indeterminate | Allred score > 2 | SUVmean > 1.5 |
| Venema (37) | 13 | 0.99 (0.73–1) | 0.96 (0.33–1) | ≥1% of cells | SUVmax > 1.5 |
| Gemignani (29) | 48 | 0.85 (0.71–0.93) | 0.74 (0.41–0.93) | ≥1% of cells | SUVmean > 1.5 |
| Yang (35) | 18 | 0.99 (0.73–1) | 0.85 (0.48–0.97) | ≥1% of cells | SUVmax > 1.5 |
| Peterson (38) | |||||
| Nonbreast | 3 | 0.97 (0.43–1) | 0.96 (0.33–1) | ≥5% of cells | SUVmean > 1 |
| Breast | 9 | 0.99 (0.69–1) | 0.66 (0.21–0.93) | ≥5% of cells | SUVmean > 1 |
| Gupta (39) | |||||
| Nonbreast | 4 | 0.98 (0.50–1) | Indeterminate | All ER+ were ≥15% of cells | Qualitative |
| Breast | 6 | 0.98 (0.60–1) | Indeterminate | ||
| Unclear location | 2 | ||||
| Chae (40) | 85 | 0.77 (0.63–0.86) | 1.00 (0.90–1) | Allred score ≥ 3 | Qualitative |
| Chae (30) | 24 | 0.92 (0.75–0.98) | Indeterminate | Allred score ≥ 6 | Qualitative |
| Dehdashti (41) | 11 | 0.69 (0.44–0.86) | 1 (0.83–1) | RBA, >3 fmol/mg or IHC* | Qualitative |
| Mintun (42) | 8 | 0.99 (0.67–1) | 0.05 (0–0.67) | RBA, >3 fmol/mg | Qualitative |
| Mortimer (43) | 16 | 0.76 (0.55–0.89) | 1 (0.83–1) | RBA, >3 fmol/mg or IHC* | Qualitative |
| van Kruchten (4) | 22 | 0.95 (0.79–0.99) | 0.99 (0.71–1) | IHC* or clinical outcome | SUVmax > 1.5 |
↵* Criteria not stated.
IHC = immunohistochemistry; RBA = radioligand binding affinity (50).
Data in parentheses are 95% confidence intervals.