TABLE 3

Clearance Fractions and Therapeutic Doses Calculated by Cumulative-Activity Method and Residence-Time Method

Clearance fractionCalculated therapeutic dose
Patient no.Fast component (%)Slow component (%)Cumulative-activity method (mCi)Residence-time method (mCi)
123.476.683.6675.66
2*93.1593.2
3811988.9471.75
458.541.593.4292.46
5*98.4293.95
6*116.6108.72
734.965.199.9380.99
822.777.3100.4782.68
9*99.7493.89
106535135.00120.82
1130.969.1103.6683.80
1253.246.8116.5390.82
137921171.09167.85
  • * Single component.