Incidence of Adverse Reactions to Iodinated Intravenous Contrast Agents (10–13,16–18)
| Reaction type | Ionic | Nonionic | Ionic HOCM | Nonionic LOCM/IOCM |
| Mild | 15% | 3% | ||
| Moderate | 1%–2% | 0.2%–0.4% | ||
| Severe | 0.2% | 0.04% | 0.22% | 0.04% |
| Fatal | 0.0006% | 0.0006% | ||
| Overall | 13% | 3% | ||
| Delayed | 2%–4% for nonionic dimer | 0.5%–1% for ionic and nonionic monomers | 12.5% for CT with intravenous contrast | 10% for CT without intravenous contrast |
| Extravasation | 0.04%–0.2% for mechanical power injectors | 0.04%–0.2% for mechanical power injectors | ||
| Contrast-induced nephropathy | 1%–3% in normal renal function | 12%–27% in renal impairment | 50% in diabetic nephropathy |