Optimization Process Applied to Different Procedural Steps Accompanied by Operational Questions and Clarification Resources

StepQuestionMain source
Radiopharmaceutical administrationWhat is radiopharmaceutical’s biodistribution and dosimetry?International Commission on Radiological Protection 128
TechnologyCan I decrease injected activity, maintaining diagnostic accuracy?Manufacturer’s specifications; diagnostic reference levels
ProtocolAre there any alternative methods? Are they appropriate? (SPECT vs. SPECT/CT; PET/CT vs. PET/MR)EANM and SNMMI guidelines; sister societies’ guidelines (e.g., ASNC)
ImagingPatient comfort? Occupational dosimetry?EANM and SNMMI guidelines