Optimization Process Applied to Different Procedural Steps Accompanied by Operational Questions and Clarification Resources
| Step | Question | Main source |
| Radiopharmaceutical administration | What is radiopharmaceutical’s biodistribution and dosimetry? | International Commission on Radiological Protection 128 |
| Technology | Can I decrease injected activity, maintaining diagnostic accuracy? | Manufacturer’s specifications; diagnostic reference levels |
| Protocol | Are there any alternative methods? Are they appropriate? (SPECT vs. SPECT/CT; PET/CT vs. PET/MR) | EANM and SNMMI guidelines; sister societies’ guidelines (e.g., ASNC) |
| Imaging | Patient comfort? Occupational dosimetry? | EANM and SNMMI guidelines |