TABLE 7

Use of Data for 2- to 8-Hour Stable Elimination Period to Calculate Elimination Rate Constant and Backproject Elimination Curve by Calculating Earlier Values (Bold) for Elimination Confounded by Absorption

Time (h)Plasma concentration (μg/mL)Elimination curve concentrationR (elimination – plasma)
0037.837.8
0.51632.416.4
12227.85.8
1.522
21919
41111
65.65.6
83.23.2