Use of Data for 7- to 24-Hour Stable Elimination Period to Calculate Elimination Rate Constant and Backproject Elimination Curve by Calculating Earlier Values (Bold) for Elimination Confounded by Absorption
Time (h) | Plasma concentration (U/L) | Elimination curve concentration | R (elimination – plasma) |
0 | 0 | 81.8 | 81.8 |
1 | 31.3 | 77.9 | 46.6 |
2 | 49.3 | 74.0 | 24.7 |
3 | 58.6 | 70.7 | 12.1 |
4 | 62.5 | 67.1 | 4.6 |
5 | 62.8 | 64.1 | 1.3 |
7 | 58.1 | 58.1 | |
10 | 50.6 | 50.6 | |
16 | 36.1 | 36.1 | |
24 | 25.3 | 25.3 |