Guidelines for Waiting Periods Between MBI Examination and Other Imaging Procedures

ModalityProcedureAdministered doseRecommended waiting period
CTWith or without contrastNone
MRIWith or without contrastNone
PETAll radiopharmaceuticalsNone
Nuclear medicine99mTc-sestamibi for parathyroid (or cardiac rest only) studies370–1,110 MBq (10–30 mCi)None*
99mTc-radiopharmaceuticals, intravenous or oral>740 MBq (20 mCi)>12 h
>370 MBq (10 mCi)>24 h
>185 MBq (5 mCi)>24 h
<185 MBq (5 mCi)>36 h
99mTc-sulfur colloid (sentinel node)<19 MBq (500 μCi)>24 h
123I-based radiopharmaceuticals>370 MBq (10 mCi)None
<37 MBq (1 mCi)>24 h
111In- and 67Ga-based radiopharmaceuticalsNone
  • These are general guidelines and in some cases may overestimate waiting period needed, depending on biologic distribution of radiopharmaceutical.

  • * May consider combining dose administration. In cases of prior administration of 99mTc-sestamibi for cardiac or parathyroid studies, reduced (or no dose) of 99mTc-sestamibi may be used, depending on residual activity from prior study.