Mechanisms of Radiopharmaceutical Accumulation in Inflamed Tissue

18F-FDGMacrophages (metabolically active cells), leukocytes
99mTc/111In-labeled autologous WBCs (leukocytes)Active migration into sites of inflammation
99mTc-labeled bisphosphonatesUptake in sites of increased perfusion and extravasation (early phase) and increased bone formation (late phase)
67Ga-citrateIncreased perfusion, extravasation due to increased vessel permeability, locally binding to lactoferrin
99mTc-labeled nanocolloidsUptake in macrophages (inflammation, bone marrow, liver, spleen)
99mTc/111In-labeled proteins (IgG, albumin)Extravasation (increased perfusion and vessel permeability)