Adenosine and Regadenoson Symptoms
| Symptom | Adenosine (n = 267) | Regadenoson (n = 517) | P (Fisher exact test) |
|---|---|---|---|
| Any event | 210 (79) | 409 (79) | 0.93 |
| Any severe event | 18 (7) | 25 (5) | 0.32 |
| Flushing | 63 (24) | 86 (17) | 0.02 |
| Dyspnea | 49 (18) | 128 (25) | 0.05 |
| Headache | 42 (16) | 148 (29) | <0.001 |
| Chest discomfort | 42 (16) | 57 (11) | 0.07 |
| Chest pain | 34 (13) | 41 (8) | 0.04 |
| Angina pectoris | 22 (8) | 40 (8) | 0.78 |
| Feeling hot | 17 (6) | 19 (4) | 0.10 |
| Nausea | 12 (4) | 29 (6) | 0.61 |
| Dizziness | 9 (3) | 35 (7) | 0.05 |
| Abdominal discomfort | 5 (2) | 32 (6) | <0.01 |
Data are presented as number of patients, with percentage in parentheses. Medical Dictionary for Regulatory Activities–preferred terms reported by 5% of patients or more in either treatment at any time after start of infusion are shown. Symptoms did not vanish with regadenoson and, in fact, differed little in their frequency, compared with those related to adenosine administration. This similarity may be related, in part, to the methods applied to determine the presence of symptoms. Adapted with permission of (35).