Methods to Test CFR

Direct tests of CFR (vasodilator stress agents)Indirect tests of CFR (exercise/dobutamine)
Seek to provoke flow heterogeneitySeek to provoke ischemia (perfusion or wall motion abnormality)
Best suited for perfusion endpointFits either perfusion or function ischemic endpoint (must be used with wall motion endpoint)
Less likely influenced by antianginal drugsVary in ability to augment flow demands and test CFR
Strongest, most reproducible, tests of CFRPermit serial function analysis
  • Adapted from (3).