Effect of Labeling Activity and Storage Form on Radiochemical Impurities in Stabilized 99mTc-d,l-HMPAO in Vials and Syringes over Time
| 1,110 MBq | 2,600–3,700 MBq | |||||||
|---|---|---|---|---|---|---|---|---|
| 99mTcO2 + secondary 99mTc-HMPAO | 99mTcO4− | 99mTcO2 + secondary 99mTc-HMPAO | 99mTcO4− | |||||
| Time (h) | Vial | Syringe | Vial | Syringe | Vial | Syringe | Vial | Syringe |
| 0 | 4.8 ± 0.9 | NA | 2.1 ± 0.9 | NA | 6.2 ± 1.2 | NA | 2.3 ± 0.7 | NA |
| 2 | 5.5 ± 0.9 | 6.2 ± 1.2 | 2.4 ± 0.5 | 4.0 ± 1.6 | 7.0 ± 1.4 | 8.1 ± 1.5 | 4.1 ± 1.2 | 6.0 ± 1.2 |
| 4 | 6.1 ± 0.8 | 6.3 ± 0.9 | 2.8 ± 0.6 | 5.0 ± 1.7 | 8.6 ± 1.7 | 9.3 ± 1.9 | 6.2 ± 1.7 | 10.4 ± 2.5 |
NA = not applicable.
Values represent percentage of radiochemical impurities (mean ± SD); n = 10. P < 0.01 for 99mTcO2 + secondary 99mTc-HMPAO and 99mTcO4− between both groups of activities in vial and syringe at all times. P > 0.05 for 99mTcO4− between both groups of labeling activities in vial at t = 0.