Effects of Faulty Radiopharmaceutical Preparation on Bone Scan
| Fault | Effect on bone scan |
|---|---|
| Free pertechnetate due to presence of air in container, a long-standing preparation, an inappropriate amount of stannous ion, or altered preparation | Thyroid uptake on early images (blood pool) and stomach, gastrointestinal tract, and salivary gland uptake |
| Colloid formation due to aluminum | Diffuse liver uptake and reduced bone uptake |
| High pH in the preparation | Liver, gallbladder, and gastrointestinal tract uptake |
| Drug interaction: | |
| Diphosphonates, etidronate | Decreased bone uptake |
| Iron | Increased soft-tissue uptake; renal cortex uptake |
| Chemotherapy | Renal cortex uptake and diffuse skull uptake |