TABLE 3.

Effect of Vincristine on the Biodistribution of Technetium-99m DTPA in Mice

Organ% Uptake
Control (n = 15)Treated (n = 15)
Thymus0.0103 ± 0.00860.0353 ± 0.0024
Lymph node inguinal0.0141 ± 0.00270.0670 ± 0.0056
Lymph node mesenteric0.0201 ± 0.00740.0481 ± 0.0125
Ovary0.0107 ± 0.00740.0475 ± 0.0112
Uterus0.0204 ± 0.00160.1350 ± 0.0098
Spleen0.0134 ± 0.00680.0410 ± 0.0112
Kidney0.1587 ± 0.04680.7891 ± 0.0115
Heart0.0165 ± 0.00180.1632 ± 0.0691
Stomach0.0334 ± 0.01920.2334 ± 0.0142
Lung0.0272 ± 0.00950.4783 ± 0.0181
Liver0.0668 ± 0.01220.3564 ± 0.0102
Bone0.0162 ± 0.00360.1101 ± 0.0311
Pancreas0.0194 ± 0.00180.0130 ± 0.0021
Thyroid0.0871 ± 0.01230.0760 ± 0.0151
Brain0.0610 ± 0.01320.0699 ± 0.0211