Large Clinical Trials and Cohort Studies Using 123I-MIBG for Heart Failure Prognostication and PD or DLB Diagnosis
| Indication | Study | Type of study | Year | Study patients | Delayed time | Delayed HMR threshold or mean ± SD | WR threshold or mean ± SD |
|---|---|---|---|---|---|---|---|
| Heart failure | Seo et al. | Single center | 2022 | 148 | 3.3 h | 1.9 | |
| Nakata et al. | Multicenter | 2013 | 1322 | 3–4 h | 1.68 | 43% | |
| Doi et al. | Single center | 2012 | 468 | 4 h | 1.57 and 1.50 ± 0.36 | 41.3% ± 9.8% | |
| Jacobson et al. | Multicenter | 2010 | 961 | 3 h 50 min | 1.6 and 1.39 ± 0.18 | 41.8% ± 17.3% | |
| Nakata et al. | Single center | 1998 | 414 | 3–4 h | 1.74 and 1.56 ± 0.36 | ||
| PD or DLB | Odagiri et al. | Single center | 2016 | 54 | 3 h | 1.59 ± 0.34 for PD/1.31 ± 0.21 for DLB | |
| Oka et al. | Single center | 2011 | 110 | 3–4 h | 1.58 ± 0.43 | ||
| Kashihara et al. | Single center | 2006 | 188 | 4 h | 1.37 ± 0.27 for PD/1.47 ± 0.37 for DLB | ||
| Nagayama et al. | Single center | 2005 | 391 | 4 h | 1.38 ± 0.29 for PD/1.17 ± 0.06 for DLB |
Variety of delayed times were used, with 4 h being most common. Various thresholds and mean values for delayed HMR and WR were used or discovered. 1.6 delayed HMR threshold used in ADMIRE-HF trial does tend to fit many trial thresholds and mean values (32,46,48,55–60).