TABLE 6.

Approved Amyloid PET Neuro Packages (FDA 510k and Conformité Européenne Mark)

CompanyNeuro packageFeatures
Syntermed, https://syntermed.com/neuroqNeuroQGenerates z scores and cortex–to–whole-cerebellum ratio based on standard SUVR
Hermes Medical Solutions, https://www.hermesmedical.com/our-software/neurology/BRASSGenerates SUVR relative to whole cerebellum and z score based on reference database of 80 healthy controls (≥2 in region of interest is considered positive)
MIM Software, https://www.mimsoftware.com/nuclear_medicine/mim_neuroMIMNeuroUses standardized PET template registration to generate voxel-based surface projections, regional and mean SUVR, and z score statistics without need for MRI; has also implemented centiloid scale across multiple tracers
Siemens Healthineers, https://www.siemens-healthineers.com/digital-health-solutions/syngoviaSyngo.VIAUses positive SUVR cutoff of ≥1.17 and further cutoff of ≥1.08 to assess identifiable levels of amyloid plaques
GE HealthCare, https://www.gehealthcare.com/courses/aw-cortex-idCortexIDGenerates SUVR and z score surface projection maps of individual patients
Qubiotech, https://qubiotech.com/en/solutions/neurocloud-pet/Neurocloud PETGenerates individual SUVR using whole cerebellum as reference region