Duration of Breastfeeding Interruption (Studies Listed Alphabetically from T to Z)

StudyRadiopharmaceuticalAdministered doseInstitution guidelines, 2022SNMMI/EANM procedure guideline (7)*Stabin and Breitz (2)ICRP 106 (8)Leide- Svegborn (1)ACMUI (9)
Thyroid scan123I-NaI18.5 MBq4 dNA0>3 wkNA3 d
Thyroid scan99mTc-pertechnetate370 MBq12 hNA4 h12 h12 h24 h
Thyroid uptake131I-NaI0.37 MBqStopNAStop>3 wkStopStop
Thyroid ablation (hyperthyroidism)131I-NaI185–1,110 MBqStopStopStop>3 wkStopStop
Thyroid cancer ablation§131I-NaI1,100–7,400 MBqStop 3 mo priorStopStop>3 wkStopStop
Urea breath test14C-urea0.037 MBq0NANA0NANA
WBC scan111In-oxine WBC10–40 MBq0NA00NA6 d
WBC scan99mTc-HMPAO WBC370–740 MBq24 hNA48 h12 h024 h
90Y-radiolabeled therapy90Y-ibritumomab tiuxetan15 MBq/kgStopNANANANA
  • * Or publicly available guidance documents.

  • Recommendation was based on both internal and external radiation exposure.

  • Single 24-h interruption period is recommended for 99mTc-labeled radiopharmaceuticals to simplify guidance.

  • § For radioiodine ablation for thyroid cancer, discontinuation of breastfeeding of 3 mo is recommended before therapy to reduce radiation exposure to lactating breast.

  • NA = data not available; 0 = no breastfeeding cessation is necessary; WBC = white blood cell; HMPAO = hexamethylpropyleneamine oxime; — = not institutional procedure.