CA Red Flags

CategoryRed flag
ClinicalHeart failure and intolerance to β-blockers and angiotensin-converting enzyme inhibitors
Heart failure and peripheral or autonomic neuropathy
Left ventricular hypertrophy with persistently elevated troponin levels
History of bilateral carpal tunnel release
Periorbital purpura
Heart failure with nephrotic syndrome
Spontaneous tendon rupture, especially biceps tendon rupture (Popeye sign)
Lumbar spinal stenosis
Plasma cell dyscrasia: elevated free light chains or abnormal serum or urine immunofixation
EchocardiographicUnexplained left ventricular hypertrophy with…
 Biatrial enlargement
 Pericardial effusion
 Reduced global longitudinal strain, characteristically apical-sparing pattern
 Low-flow, low-gradient aortic stenosis
ElectrocardiographicLow-voltage QRS complex in setting of left ventricular hypertrophy