Clinical Eligibility Criteria for Therapy (14)
| Clinical metric | Requirement |
|---|---|
| Castration-resistant prostate cancer metastatic to bone | Symptomatic |
| No visceral metastatic disease | |
| Whole-body bone scan with at least 2 lesions | |
| Complete blood count with differential | Before first treatment: |
| Absolute neutrophil count ≥ 1.5 × 109/L | |
| Platelet count ≥ 100 × 109/L | |
| Hemoglobin ≥ 10 g/dL | |
| Before subsequent administration: | |
| Absolute neutrophil count = 1 × 109/L | |
| Platelet count = 50 × 109/L | |
| No hemoglobin requirement |