Parameter | Exclusion criterion |
---|---|
Serum creatinine | >150 μmol/L (>1.7 mg/dL) or creatinine clearance < 50 mL/min |
Hemoglobin | <5.0 mmol/L (<8.0 g/dL) |
White-cell count | <2,000/mm3 (2 × 109/L) |
Platelet count | <75,000/mm3 (75 × 109/L) |
Total bilirubin | >3 times upper limit of reference range |
Serum albumin | <25 g/L and prothrombin time increased 1.5 times upper limit of reference range* |
* Indicates biosynthetic liver failure.