PT  - JOURNAL ARTICLE
AU  - Sunita Nitin Sonavane
AU  - Sandip Basu
TI  - Differential tumor biology between locoregional and distant metastasis in a patient with TENIS with TKI-resistant aggressive recurrent disease: a comparative evaluation with FDG, <sup>68</sup>Ga-DOTATATE and <sup>68</sup>Ga-PSMA-11 PET-CT
AID  - 10.2967/jnmt.121.263452
DP  - 2021 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - jnmt.121.263452
4099  - http://tech.snmjournals.org/content/early/2021/12/06/jnmt.121.263452.short
4100  - http://tech.snmjournals.org/content/early/2021/12/06/jnmt.121.263452.full
AB  - The molecular PET-CT imaging profile of an interesting case of differentiated thyroid carcinoma, later transformed into with thyroglobulin elevation and negative iodine scintigraphy (TENIS) with tyrosine kinase inhibitor (TKI) resistant recurrent aggressive disease, is presented. The patient was evaluated to assess SSTR-2 or PSMA expression to explore the possibility of any effective targeted nuclear therapy. 18F-FDG, 68Ga-DOTATATE and 68Ga-PSMA-11 PET/CT was performed, which revealed tracer avidity in all 3 scans in the extensive loco-regional disease of large ill-defined retropharyngeal and retro-tracheal soft tissue eroding cricoid cartilage, extending into tracheal lumen and left sided strap muscles. On the contrary, there was no definite uptake in the multiple bilateral lung nodules, the scan findings indicating a differential tumor biology between loco-regional and distant metastasis.