PT - JOURNAL ARTICLE AU - Mehdi Djekidel AU - Mark Michalski TI - Hybrid Imaging with SPECT-CT and SPECT-MR in Hepatic Splenosis. AID - 10.2967/jnmt.121.263013 DP - 2021 Dec 01 TA - Journal of Nuclear Medicine Technology PG - jnmt.121.263013 4099 - http://tech.snmjournals.org/content/early/2021/12/06/jnmt.121.263013.short 4100 - http://tech.snmjournals.org/content/early/2021/12/06/jnmt.121.263013.full AB - Splenosis, commonly occurs incidentally and locates to bowel surfaces, parietal peritoneum, mesentery, and diaphragm, but can potentially occur anywhere in the peritoneal cavity. Patients frequently have a history of splenectomy or trauma. On the other hand, hepatic splenosis is a rare entity and may present itself clinically. Indeterminate liver lesions can pose a clinical dilemma and may lead to additional investigations, anxiety, follow-up imaging and even to invasive procedures. MRI usually performs extremely well. In difficult cases, scintigraphy can be of great value –especially with novel SPECT-CT and SPECT-MR techniques-. We describe a case of a 29-year-old lady with hepatic splenosis and the impact of hybrid imaging.