TY - JOUR T1 - Validation of a Paper Chromatographic Methodology as an Alternative for Determination of the Radiochemical Purity of Na<sup>18</sup>F JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 271 LP - 274 DO - 10.2967/jnmt.112.107664 VL - 40 IS - 4 AU - Natalia M. Leonardi AU - Guillermo A. Casale AU - Jorge Nicolini AU - Patricia D. Zubata AU - María J Salgueiro AU - Marcela B. Zubillaga Y1 - 2012/12/01 UR - http://tech.snmjournals.org/content/40/4/271.abstract N2 - The aim of the present work was to validate a paper chromatography system as an alternative way to determine the radiochemical purity of Na18F. Methods: The evaluated parameters were specificity, limit of quantification, measurement interval, linearity, precision, accuracy, and robustness. Results: The proposed method proved to be linear (P &gt; 0.05; r2 = 1.000), precise (relative SD, 8.6%), accurate (mean recovery, 95.9%; relative SD, 1.5%–1.8%), and robust under different conditions since no influence of the operative variables on the chromatographic performance was observed. Conclusion: This system can be used as a reliable alternative method to determine the radiochemical purity of Na18F samples that can be easily performed in PET radiopharmacies at low cost. ER -