RT Journal Article SR Electronic T1 Validation of a Paper Chromatographic Methodology as an Alternative for Determination of the Radiochemical Purity of Na18F JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 271 OP 274 DO 10.2967/jnmt.112.107664 VO 40 IS 4 A1 Natalia M. Leonardi A1 Guillermo A. Casale A1 Jorge Nicolini A1 Patricia D. Zubata A1 María J Salgueiro A1 Marcela B. Zubillaga YR 2012 UL http://tech.snmjournals.org/content/40/4/271.abstract AB The aim of the present work was to validate a paper chromatography system as an alternative way to determine the radiochemical purity of Na18F. Methods: The evaluated parameters were specificity, limit of quantification, measurement interval, linearity, precision, accuracy, and robustness. Results: The proposed method proved to be linear (P > 0.05; r2 = 1.000), precise (relative SD, 8.6%), accurate (mean recovery, 95.9%; relative SD, 1.5%–1.8%), and robust under different conditions since no influence of the operative variables on the chromatographic performance was observed. Conclusion: This system can be used as a reliable alternative method to determine the radiochemical purity of Na18F samples that can be easily performed in PET radiopharmacies at low cost.