%0 Journal Article %A Natalia M. Leonardi %A Guillermo A. Casale %A Jorge Nicolini %A Patricia D. Zubata %A María J Salgueiro %A Marcela B. Zubillaga %T Validation of a Paper Chromatographic Methodology as an Alternative for Determination of the Radiochemical Purity of Na18F %D 2012 %R 10.2967/jnmt.112.107664 %J Journal of Nuclear Medicine Technology %P 271-274 %V 40 %N 4 %X The aim of the present work was to validate a paper chromatography system as an alternative way to determine the radiochemical purity of Na18F. Methods: The evaluated parameters were specificity, limit of quantification, measurement interval, linearity, precision, accuracy, and robustness. Results: The proposed method proved to be linear (P > 0.05; r2 = 1.000), precise (relative SD, 8.6%), accurate (mean recovery, 95.9%; relative SD, 1.5%–1.8%), and robust under different conditions since no influence of the operative variables on the chromatographic performance was observed. Conclusion: This system can be used as a reliable alternative method to determine the radiochemical purity of Na18F samples that can be easily performed in PET radiopharmacies at low cost. %U https://tech.snmjournals.org/content/jnmt/40/4/271.full.pdf