PT - JOURNAL ARTICLE AU - Harwood, Matthew AU - Craig, Fiona E AU - Yang, Ming TI - Rare Multi-system Histiocytic Sarcoma on F18-FDG PET/CT AID - 10.2967/jnmt.121.262247 DP - 2021 Jul 01 TA - Journal of Nuclear Medicine Technology PG - jnmt.121.262247 4099 - http://tech.snmjournals.org/content/early/2021/07/30/jnmt.121.262247.short 4100 - http://tech.snmjournals.org/content/early/2021/07/30/jnmt.121.262247.full AB - Histiocytic sarcoma (HS) is a rare malignancy with morphological and immunophenotypic features of histocytes. We present a case of histiocytic sarcoma with multisystem involvement, including an obstructing pancreatic head mass. F18-FDG PET/CT is a valuable tool in staging and assessment of response to therapy in this rare entity. Knowing the diverse metastatic pattern of HS will help avoid imaging pitfalls for the diagnosis after pathologic diagnosis is made.