PT  - JOURNAL ARTICLE
AU  - Jain, Tarun Kumar
AU  - Krishnaraju, Venkata Subramanian
AU  - Mittal, Bhagwant Rai
AU  - Sood, Ashwani
AU  - Kumar, Rajender
AU  - Garg, Rashi
AU  - Kumar, Sunil
TI  - Follicular thyroid carcinoma with unusual radioiodine refractory breast metastasis mimicking primary breast malignancy
AID  - 10.2967/jnmt.120.259259
DP  - 2021 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - jnmt.120.259259
4099  - http://tech.snmjournals.org/content/early/2021/03/12/jnmt.120.259259.short
4100  - http://tech.snmjournals.org/content/early/2021/03/12/jnmt.120.259259.full
AB  - Breast is unusual site for metastasis from malignant tumors though may be the first manifestation of extra-mammary malignancy with primary typically arising from lung, melanoma, ovary and lymphoma. Breast metastasis is extremely rare from thyroid carcinoma and may take years to develop as differentiated thyroid carcinoma are usually indolent, slow growing and metastasize to lymph nodes, lungs and bones. Here is a middle-aged woman (post-subtotal thyroidectomy for multi-nodular goitre 24 years ago) showing discordant FDG and iodine avidity in proven metastatic disease involving lymph nodes, bones, spleen and breast on whole-body radioiodine and FDG-PET/CT due to tumor heterogeneity.