PT  - JOURNAL ARTICLE
AU  - Si, Hongwei
AU  - Li, Xianfeng
TI  - Abundant Blood Supply and Low P-Glycoprotein Expression on Dynamic <sup>99m</sup>Tc-MIBI Imaging Predicted Better Chemotherapy Sensitivity for a Breast Cancer Patient: A Case Report
AID  - 10.2967/jnmt.111.099309
DP  - 2012 Jun 01
TA  - Journal of Nuclear Medicine Technology
PG  - 89--91
VI  - 40
IP  - 2
4099  - http://tech.snmjournals.org/content/40/2/89.short
4100  - http://tech.snmjournals.org/content/40/2/89.full
SO  - J. Nucl. Med. Technol.2012 Jun 01; 40
AB  - A patient with a history of breast cancer underwent 3-phase 99mTc-methylene diphosphonate (MDP) imaging followed 3 d later by 3-phase 99mTc-sestamibi (MIBI) imaging. During the vascular and blood-pool phases, a lymph node over the right clavicle was seen on both the 99mTc-MIBI and the 99mTc-MDP scans at as early as 30 s and then became hotter. Four months after receiving chemotherapy, the patient achieved a complete response. The lymph node over the right clavicle vanished on ultrasound examination. The similar distribution of the blood-pool phase between the 99mTc-MDP and 99mTc-MIBI scans indicated that 99mTc-MIBI may similarly provide information on vascularization of the lymph node. In addition to indicating vascularization, our 99mTc-MIBI protocol may simultaneously provide information on P-glycoprotein expression important for predicting chemotherapy sensitivity. With information on the resistance of a tumor to drugs and the environment in which it dwells, chemotherapy sensitivity might be predicted more precisely.