PT - JOURNAL ARTICLE AU - Nghi C. Nguyen AU - Sushil Beriwal AU - Chan-Hong Moon AU - Alessandro Furlan AU - James M. Mountz AU - Balasubramanya Rangaswamy TI - <sup>18</sup>F-FDG PET/MRI Primary Staging of Cervical Cancer: A Pilot Study with PET/CT Comparison AID - 10.2967/jnmt.120.247080 DP - 2020 Dec 01 TA - Journal of Nuclear Medicine Technology PG - 331--335 VI - 48 IP - 4 4099 - http://tech.snmjournals.org/content/48/4/331.short 4100 - http://tech.snmjournals.org/content/48/4/331.full SO - J. Nucl. Med. Technol.2020 Dec 01; 48 AB - We report our PET/MRI experience from a pilot study that compared the diagnostic performance of 18F-FDG PET/MRI versus PET/CT in staging of cervical cancer. Methods: Six adults with newly diagnosed cervical cancer underwent a single 18F-FDG injection with a dual-imaging protocol: standard-of-care PET/CT followed by research PET/MRI. The diagnostic interpretation and SUVmax for the 2 modalities were compared. Results: Both modalities detected all primary tumors (median size, 3.9 cm) and all 4 metastases present in 2 of the 6 patients (median size, 0.9 cm). PET/MRI provided greater diagnostic confidence than PET/CT and upstaged the disease in 4 patients. On the basis of the imaging findings alone, the additional information from PET/MRI would have led to a change in clinical management in 3 of 6 patients. The primary lesion showed a median SUV of 12.8 on PET/CT and 18.2 on PET/MRI (P = 0.03). SUVs, however, correlated strongly between the 2 modalities (ρ = 0.96, P &lt; 0.001). Conclusion: Our pilot study supports the notion that PET/MRI has the potential to impact clinical decisions and treatment strategies in women with cervical cancer. Further studies are, however, warranted to define the value that PET/MRI adds to PET/CT.