@article {Nguyen331, author = {Nghi C. Nguyen and Sushil Beriwal and Chan-Hong Moon and Alessandro Furlan and James M. Mountz and Balasubramanya Rangaswamy}, title = {18F-FDG PET/MRI Primary Staging of Cervical Cancer: A Pilot Study with PET/CT Comparison}, volume = {48}, number = {4}, pages = {331--335}, year = {2020}, doi = {10.2967/jnmt.120.247080}, publisher = {Society of Nuclear Medicine}, abstract = {We report our PET/MRI experience from a pilot study that compared the diagnostic performance of 18F-FDG PET/MRI versus PET/CT in staging of cervical cancer. Methods: Six adults with newly diagnosed cervical cancer underwent a single 18F-FDG injection with a dual-imaging protocol: standard-of-care PET/CT followed by research PET/MRI. The diagnostic interpretation and SUVmax for the 2 modalities were compared. Results: Both modalities detected all primary tumors (median size, 3.9 cm) and all 4 metastases present in 2 of the 6 patients (median size, 0.9 cm). PET/MRI provided greater diagnostic confidence than PET/CT and upstaged the disease in 4 patients. On the basis of the imaging findings alone, the additional information from PET/MRI would have led to a change in clinical management in 3 of 6 patients. The primary lesion showed a median SUV of 12.8 on PET/CT and 18.2 on PET/MRI (P = 0.03). SUVs, however, correlated strongly between the 2 modalities (ρ = 0.96, P \< 0.001). Conclusion: Our pilot study supports the notion that PET/MRI has the potential to impact clinical decisions and treatment strategies in women with cervical cancer. Further studies are, however, warranted to define the value that PET/MRI adds to PET/CT.}, issn = {0091-4916}, URL = {https://tech.snmjournals.org/content/48/4/331}, eprint = {https://tech.snmjournals.org/content/48/4/331.full.pdf}, journal = {Journal of Nuclear Medicine Technology} }