RT Journal Article
SR Electronic
T1 Small Cell Transformation of Metastatic Prostate Adenocarcinoma Diagnosed by Dual Tracer PET/CT (68Ga-PSMA and 18F-FDG): Potential Clinical Utility in Therapeutic Decision-Making and Treatment Monitoring
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP jnmt.118.215582
DO 10.2967/jnmt.118.215582
A1 Rahul Vithalrao Parghane
A1 Sandip Basu
YR 2018
UL http://tech.snmjournals.org/content/early/2018/08/22/jnmt.118.215582.abstract
AB Transformed small cell carcinoma of prostate represents a distinct tumor biology from the adenocarcinoma counterpart and penile metastasis from prostate cancer is a rare entity. Unique features of this transformation include unresponsiveness to hormonal therapy and presence of visceral metastases, which can demonstrate hypermetabolism on 18F-FDG PET/CT. The importance of dual tracer PET/CT using 68Ga-PSMA and 18F-FDG is illustrated in metastatic prostatic adenocarcinoma (Gleason’s score 4+3=7) with previous history of bilateral orchidectomy, chemotherapy and radiotherapy, who presented with abdominal pain and backache, dysuria and increasing serum PSA. The value of sequential dual tracer PET/CT to assess disease status, theranostics and monitoring response to multimodality therapies is illustrated.