TY - JOUR T1 - Small Cell Transformation of Metastatic Prostate Adenocarcinoma Diagnosed by Dual Tracer PET/CT (<sup>68</sup>Ga-PSMA and <sup>18</sup>F-FDG): Potential Clinical Utility in Therapeutic Decision-Making and Treatment Monitoring JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. DO - 10.2967/jnmt.118.215582 SP - jnmt.118.215582 AU - Rahul Vithalrao Parghane AU - Sandip Basu Y1 - 2018/08/01 UR - http://tech.snmjournals.org/content/early/2018/08/22/jnmt.118.215582.abstract N2 - Transformed small cell carcinoma of prostate represents a distinct tumor biology from the adenocarcinoma counterpart and penile metastasis from prostate cancer is a rare entity. Unique features of this transformation include unresponsiveness to hormonal therapy and presence of visceral metastases, which can demonstrate hypermetabolism on 18F-FDG PET/CT. The importance of dual tracer PET/CT using 68Ga-PSMA and 18F-FDG is illustrated in metastatic prostatic adenocarcinoma (Gleason’s score 4+3=7) with previous history of bilateral orchidectomy, chemotherapy and radiotherapy, who presented with abdominal pain and backache, dysuria and increasing serum PSA. The value of sequential dual tracer PET/CT to assess disease status, theranostics and monitoring response to multimodality therapies is illustrated. ER -