RT Journal Article SR Electronic T1 18F-Sodium fluoride positron emission tomography: History, technical feasibility, mechanism of action, normal bio-distribution, and diagnostic performance in bone metastasis detection compared to other imaging modalities JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP jnmt.119.234336 DO 10.2967/jnmt.119.234336 A1 Ahuja, Kriti A1 Sotoudeh, Houman A1 Galgano, Samuel J A1 Singh, Ramandeep A1 Gupta, Nishant A1 Gaddamanugu, Siddhartha A1 Choudhary, Gagandeep YR 2019 UL http://tech.snmjournals.org/content/early/2019/12/03/jnmt.119.234336.abstract AB The skeleton is overall the third most common metastatic site after the lungs and liver. Accurate diagnosis of osseous metastasis is critical for initial staging, treatment planning, restaging, treatment monitoring and survival prediction. Currently, 99mTc-methylene diphosphonate (99mTc-MDP) whole-body scan is the cornerstone of imaging to detect osseous metastasis. Though 18F-sodium fluoride (18F-NaF) was one of the oldest medical tracers but was replaced by other tracers until recently, owing to its physical properties. Continued development of positron emission tomographic (PET) scanners have opened a new era for 18F-NaF and given its higher sensitivity, there have been increasing applications in imaging. In this review, we will discuss the history, technical aspects, radiobiology, and bio-distribution of this tracer. Finally, we compared the accuracy of 18F-NaF PET with other conventional imaging for detection of osseous metastasis.