PT  - JOURNAL ARTICLE
AU  - BLONDEEL-GOMES, Sandy
AU  - MARIE, Solène
AU  - FOUQUE, Julien
AU  - LOYEAU, Sabrina
AU  - MADAR, Olivier
AU  - LOKIEC, François
TI  - Validation of an ergonomic method to withdraw [<sup>99m</sup>Tc] radiopharmaceuticals
AID  - 10.2967/jnmt.117.199133
DP  - 2017 Nov 01
TA  - Journal of Nuclear Medicine Technology
PG  - jnmt.117.199133
4099  - http://tech.snmjournals.org/content/early/2017/11/08/jnmt.117.199133.short
4100  - http://tech.snmjournals.org/content/early/2017/11/08/jnmt.117.199133.full
AB  - The main objective of the present work was to ensure quality of radiopharmaceuticals syringes withdrawn with a “Spinal needle/obturator In-Stopper” system. Methods: Visual examinations and physicochemical tests are performed at T0 and T+4h for [99mTc]albumin nanocolloid and T+7h for [99mTc]eluate, [99mTc] HydroxyMethylene DiPhosphonate and [99mTc]Human Serum Albumin. Microbiological validation was performed according to European pharmacopoeia. Fingertip radiation exposure was evaluated to confirm the safety of the system. Results: Results show stable visual and physicochemical properties. The integrity of the connector was not affected after 30 punctures (no cores). No microbiological contamination was found on tested syringes. Conclusion: The system could be used 30 times. The stability of syringes drawing with this method is guaranteed up to 4 hours for [99mTc]albumin nanocolloid and 7 hours for [99mTc]eluate, [99mTc]HydroxyMethylene DisPhosphonate and [99mTc]Human serum albumin.