PT - JOURNAL ARTICLE AU - Leonardi, Natalia M. AU - Casale, Guillermo A. AU - Nicolini, Jorge AU - Zubata, Patricia D. AU - Salgueiro, María J AU - Zubillaga, Marcela B. TI - Validation of a Paper Chromatographic Methodology as an Alternative for Determination of the Radiochemical Purity of Na<sup>18</sup>F AID - 10.2967/jnmt.112.107664 DP - 2012 Dec 01 TA - Journal of Nuclear Medicine Technology PG - jnmt.112.107664 4099 - http://tech.snmjournals.org/content/early/2012/09/26/jnmt.112.107664.short 4100 - http://tech.snmjournals.org/content/early/2012/09/26/jnmt.112.107664.full AB - The aim of the present work was to validate a paper chromatography system as an alternative way to determine the radiochemical purity of Na18F. Methods: The evaluated parameters were specificity, limit of quantification, measurement interval, linearity, precision, accuracy, and robustness. Results: The proposed method proved to be linear (P &gt; 0.05; r2 = 1.000), precise (relative SD, 8.6%), accurate (mean recovery, 95.9%; relative SD, 1.5%–1.8%), and robust under different conditions since no influence of the operative variables on the chromatographic performance was observed. Conclusion: This system can be used as a reliable alternative method to determine the radiochemical purity of Na18F samples that can be easily performed in PET radiopharmacies at low cost.