RT Journal Article SR Electronic T1 The Association of Dipyridamole Side Effects with Hemodynamic Parameters, ECG Findings, and Scintigraphy Outcomes JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 149 OP 152 DO 10.2967/jnmt.109.072629 VO 38 IS 3 A1 Hamid Javadi A1 Malihnaz Shariati A1 Mehdi Mogharrabi A1 Isa Neshandar Asli A1 Sara Jallalat A1 Aref Hooman A1 Mohammad Seyedabadi A1 Majid Assadi YR 2010 UL http://tech.snmjournals.org/content/38/3/149.abstract AB Dipyridamole has extensively been administered as a substitute for physical activity in cardiovascular assessment. The aim of this study was to evaluate the association of dipyridamole side effects with hemodynamic oscillations, scanning results, and electrocardiography (ECG) findings. Methods: Overall, 590 patients referred to the nuclear medicine center for myocardial perfusion imaging were evaluated for adverse dipyridamole effects concurrent with a low level of exercise. Before and during dipyridamole infusion, the patients’ vital signs, electrocardiogram, heart rate, systolic blood pressure, and diastolic blood pressure were monitored; all patients underwent stress–rest 99mTc-sestamibi gated SPECT using a 2-d protocol. Results: Eighty-eight patients (14.9%) experienced at least one side effect during dipyridamole infusion, and abnormal ECG and scan results were observed in 32.4% and 48.6% of patients, respectively. We observed a positive correlation between a higher incidence of chest discomfort, headache, and dyspnea and abnormalities on ECG and myocardial perfusion imaging. In addition, these 3 side effects were also associated with a higher postinfusion heart rate, lower preinfusion systolic blood pressure, and lower postinfusion diastolic blood pressure. There were significant differences between pre- and postinfusion heart rate, preinfusion systolic blood pressure, and postinfusion diastolic blood pressure among patients with or without side effects, whereas no significant difference was observed in any of the hemodynamic parameters between patients with normal and abnormal ECG results or myocardial perfusion imaging results. Conclusion: This study demonstrated a correlation between hemodynamic variables and side effects but not with imaging findings or ECG findings.