PT - JOURNAL ARTICLE AU - Caglar, Meltem AU - Kıratlı, Pınar Özgen AU - Karabulut, Erdem TI - Inter- and Intraobserver Variability of <sup>99m</sup>Tc-DMSA Renal Scintigraphy: Impact of Oblique Views AID - 10.2967/jnmt.106.036111 DP - 2007 Jun 01 TA - Journal of Nuclear Medicine Technology PG - 96--99 VI - 35 IP - 2 4099 - http://tech.snmjournals.org/content/35/2/96.short 4100 - http://tech.snmjournals.org/content/35/2/96.full SO - J. Nucl. Med. Technol.2007 Jun 01; 35 AB - 99mTc-Dimercaptosuccinic acid (DMSA) scintigraphy is a frequently used diagnostic test to assess the presence and severity of cortical damage. The aim of this study is to investigate the variability in the interpretation of 99mTc-DMSA scans, evaluate the usefulness of oblique images, and assess their impact on scan interpretation. Methods: Two experienced nuclear medicine physicians independently interpreted 100 99mTc-DMSA scans (197 kidneys) 4 times. Interpretation was twice based on posterior projection images and twice based on posterior and posterior oblique projection images. For each kidney, the observers had to choose between the following results: normal, abnormal, and indeterminate. The indices of variability used were the percentage of agreement, κ-statistic, and marginal homogeneity. Results: Intraobserver and interobserver reproducibility (κ-values) varied between 0.683 and 0.708 and between 0.609 and 0.671, respectively, for posterior images. Disagreement in 99mTc-DMSA scan interpretation occurred in 18% of kidneys within observers and in 21% of kidneys between observers when only posterior images were used. Oblique views changed the interpretation in 14% and 11.5% of kidneys for the first and second observers, respectively. The use of oblique views increased the agreement rate within and between observers (κ-values, 0.725–0.812 and 0.768–0.732, respectively; mean agreement, 86.5 and 87.25, respectively). Conclusion: Oblique views were found useful in approximately 13% of kidneys and affected inter- and intraobserver variability. Our results suggest that oblique views should be used routinely in children with clinically suspected urinary tract infection to reliably interpret images.