RT Journal Article SR Electronic T1 The Value of Quantitative Uptake of 99mTc-MDP and 99mTc-HMPAO White Blood Cells in Detecting Osteomyelitis in Violated Peripheral Bones JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 91 OP 95 DO 10.2967/jnmt.106.035402 VO 35 IS 2 A1 Ballani, Nasser S. A1 Al-Huda, Fawaz Abu A1 Khan, Haider A. A1 Al-Mohannadi, Shihab A1 Mahmood, Hanan A1 Al-Enezi, Farha YR 2007 UL http://tech.snmjournals.org/content/35/2/91.abstract AB Our objective in this study was to evaluate whether measurement of quantitative uptake of 99mTc-methylene diphosphate (MDP) and 99mTc-hexamethylpropyleneamine oxime (HMPAO) white blood cells (WBCs) is useful in detecting osteomyelitis in peripheral bony lesions. Methods: Twenty-four patients (12 men and 12 women; age range, 25–72 y) were referred for imaging because of clinically suspected osteomyelitis. They had a traumatic fracture (n = 10), knee prosthesis (n = 5), hip prosthesis (n = 2), diabetic foot (n = 4), or chronic osteomyelitis (n = 3). Three-phase bone scanning and 99mTc-HMPAO WBC studies were performed on all patients within the same week. Regions of interest were drawn over the abnormal bony sites and the contralateral normal sites, and the abnormal-to-normal uptake ratios (A/N ratios) were obtained for both studies. Results: All patients had abnormal findings on 3-phase bone scanning, whereas 17 (71%) had abnormal findings on 99mTc-HMPAO WBC studies, of which 15 were confirmed to be true-positive. In those 15 patients, the mean A/N ratios for 99mTc-MDP and 99mTc-HMPAO WBC were 3.0 ± 1.6 (range, 1.3–6.2) and 1.8 ± 0.3 (range, 1.4–2.2), respectively. In the other 9 patients, whose scan results were clinically confirmed to be true-negative, the mean A/N ratios for 99mTc-MDP and 99mTc-HMPAO WBC were 2.1 ± 1.2 and 1.2 ± 0.2, respectively. In the group with a 99mTc-MDP A/N ratio greater than 2 (n = 15), 87% (13/15) had a high 99mTc-HMPAO WBC A/N ratio (>1.5), including 2 that were false-positive. In the remaining 2 patients, one with chronic osteomyelitis and the other with a recent hip prosthesis, 99mTc-HMPAO WBC ratios were normal. In the group with a bone A/N ratio of less than 2 (n = 9), only 4 patients (44%) were true-positive for acute osteomyelitis. Conclusion: 99mTc-MDP bone scanning alone, with an A/N ratio of more than 2, is useful in detecting osteomyelitis in violated bone except in the case of a recent hip prosthesis or chronic osteomyelitis.