TY - JOUR T1 - Reproducibility of a Standardized Quantitative Analysis Using Fixed Regions of Interest to Differentiate Movement Disorders on <sup>123</sup>I-FP-CIT SPECT JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 21 LP - 26 VL - 35 IS - 1 AU - Marcel P.M. Stokkel AU - Petra Dibbets-Schneider AU - Elke Koestering AU - Constantin Dragoiescu AU - Koos A.K. Blokland Y1 - 2007/03/01 UR - http://tech.snmjournals.org/content/35/1/21.abstract N2 - The present prospective study evaluated the diagnostic value of a standardized analysis of 123I-N-ω-(fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)tropane (FP-CIT) SPECT studies acquired on a triple-head γ-camera for patients with clinically uncertain movement disorders having tremor as the most striking feature. Methods: 123I-FP-CIT studies were performed on 52 consecutive patients (27 male and 25 female; mean age, 49.2 y; range, 17–80 y) who had a clinical diagnosis of Parkinson's disease (PD) (n = 21), hypokinetic rigid syndrome (n = 19), dystonia (n = 8), or essential tremor (n = 4). In all patients, the final diagnosis was based on a thorough clinical examination, the family history, and a 2-y follow-up. Two independent technologists analyzed 123I-FP-CIT studies using a standardized quantitative method applying both fixed regions of interest (ROIs) and manually drawn ROIs. The mean values from both methods were compared using the Student t test, and the intra- and intertechnologist variabilities were tested. Results: In patients with PD, all ratios were significantly lower (P &lt; 0.001) than those in patients with other movement disorders. No significant differences were found between the other groups tested. The manual method resulted in significantly lower values than did the standardized method (P &lt; 0.001) and, for the putamen, showed significant differences between technologists. The standardized method showed no significant differences between technologists. The intra- and intertechnologist variabilities for this method were 0.14 ± 0.13 (confidence value, 2.4%) and 0.19 ± 0.18 (confidence value, 3.1%), respectively, whereas the intraclass correlation coefficients were 0.99 for 1 technologist and 0.98 for the 2 independent technologists. Conclusion: Our data confirm that 123I-FP-CIT SPECT has value in the differentiation of PD from other movement disorders. Acquisition using a triple-head γ-camera and subsequent standardized analysis using fixed ROIs result in good intra- and intertechnologist agreement and can easily be applied in clinical practice. ER -