@article {Wheat158, author = {Janelle M. Wheat and Geoffrey M. Currie}, title = {Impact of Patient Motion on Myocardial Perfusion SPECT Diagnostic Integrity: Part 2}, volume = {32}, number = {3}, pages = {158--163}, year = {2004}, publisher = {Society of Nuclear Medicine}, abstract = {Objective:Advances in 99mTc-based radiopharmaceuticals and multiple-detector gantries have the potential to increase the significance of patient motion on the diagnostic integrity of myocardial perfusion SPECT acquisitions. Methods:An experimental study was used to evaluate the effect of various patient motions on the diagnostic integrity of myocardial perfusion SPECT data using 522 motion simulations generated from a technically and diagnostically normal dataset. Results:Of studies with induced motion, 21.7\% of simulated motion demonstrated motion-induced artifacts. Abrupt motion resulted in artifacts for 52.6\% of studies, whereas bounce motion resulted in artifacts in 6.8\% of studies. The locations where motion resulted in the most studies with artifacts were at 45{\textdegree} (36.1\%) and 75{\textdegree} (32.4\%). No statistical difference was demonstrated between single, dual-, and triple-head configurations. Conclusion:Combining these results with those of the clinical evaluation of incidence indicates that patient motion during 99mTc-based myocardial perfusion SPECT studies is a potential source of false-positive findings for coronary artery disease. There is a 7.1\% probability that myocardial perfusion SPECT studies performed at the 3 sites investigated will contain a motion-induced artifact. Fully realized, this potential results in decreased test specificity and unfavorable cost and consequence outcomes.}, issn = {0091-4916}, URL = {https://tech.snmjournals.org/content/32/3/158}, eprint = {https://tech.snmjournals.org/content/32/3/158.full.pdf}, journal = {Journal of Nuclear Medicine Technology} }