RT Journal Article
SR Electronic
T1 Measurement of <sup>18</sup>F-FDG Concentrations in Blood Samples: Comparison of Direct Calibration and Standard Solution Methods
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 206
OP 209
VO 31
IS 4
A1 Greuter, Henri N.J.M.
A1 Boellaard, Ronald
A1 van Lingen, Arthur
A1 Franssen, Eric J.F.
A1 Lammertsma, Adriaan A.
YR 2003
UL http://tech.snmjournals.org/content/31/4/206.abstract
AB Objective: The purpose of this study was to compare the accuracy and reliability of 2 well counter methods for measuring the activity concentration of 18F-FDG in blood samples. Methods: Three to 5 blood samples from 154 patient studies were weighed and measured in a well counter. The 18F-FDG activity concentration was derived using, first, a direct calibration factor to convert measured well counter readings into activity concentration and, second, a comparison of measured counts with those of a specified standard solution. Results: The ratio between the activity concentration results of the 2 methods was 0.996 ± 0.033, indicating that the methods provided equal results. Conclusion: Because the standard solution method is more prone to human error, less reproducible, and more labor intensive, preference should be given to the direct calibration method.