RT Journal Article SR Electronic T1 Severe Systemic Reaction to 99mTc-Methylene Diphosphonate: A Case Report JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 76 OP 78 VO 31 IS 2 A1 Balan, Kottekkattu K. A1 Choudhary, Arabinda K. A1 Balan, Anupama A1 Wishart, Gordon YR 2003 UL http://tech.snmjournals.org/content/31/2/76.abstract AB We report an unusual severe systemic reaction that occurred in a woman after a 99mTc-methylene diphosphonate bone scan and for which no alternative explanation could be found. The bone scintigram showed diffusely increased uptake in the liver and kidneys accompanied by reversible dysfunction of these organs and dermatologic manifestations. We speculate that an immune-mediated mechanism may have caused this unusual reaction.