RT Journal Article SR Electronic T1 Quality Improvement Initiatives to Assess and Improve PET/CT Injection Infiltration Rates at Multiple Centers JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 326 OP 331 DO 10.2967/jnmt.119.228098 VO 47 IS 4 A1 Terence Z. Wong A1 Thad Benefield A1 Shane Masters A1 Jackson W. Kiser A1 James Crowley A1 Dustin Osborne A1 Osama Mawlawi A1 James Barnwell A1 Pawan Gupta A1 Akiva Mintz A1 Kelley A. Ryan A1 Steven R. Perrin A1 Ronald K. Lattanze A1 David W. Townsend YR 2019 UL http://tech.snmjournals.org/content/47/4/326.abstract AB PET/CT radiotracer infiltration is not uncommon and is often outside the imaging field of view. Infiltration can negatively affect image quality, image quantification, and patient management. Until recently, there has not been a simple way to routinely practice PET radiopharmaceutical administration quality control and quality assurance. Our objectives were to quantify infiltration rates, determine associative factors for infiltration, and assess whether rates could be reduced at multiple centers and then sustained. Methods: A “design, measure, analyze, improve, and control” quality improvement methodology requiring novel technology was used to try to improve PET/CT injection quality. Teams were educated on the importance of quality injections. Baseline infiltration rates were measured, center-specific associative factors were analyzed, team meetings were held, improvement plans were established and executed, and rates remeasured. To ensure that injection-quality gains were retained, real-time feedback and ongoing monitoring were used. Sustainability was assessed. Results: Seven centers and 56 technologists provided data on 5,541 injections. The centers’ aggregated baseline infiltration rate was 6.2% (range, 2%–16%). On the basis of their specific associative factors, 4 centers developed improvement plans and reduced their aggregated infiltration rate from 8.9% to 4.6% (P < 0.0001). Ongoing injection monitoring showed sustainability. Significant variation was found in center- and technologist-level infiltration rates (P < 0.0001 and P = 0.0020, respectively). Conclusion: A quality improvement approach with new technology can help centers measure infiltration rates, determine associative factors, implement interventions, and improve and sustain injection quality. Because PET/CT images help guide patient management, the monitoring and improvement of radiotracer injection quality are important.