PT  - JOURNAL ARTICLE
AU  - Joanie MacDonald
TI  - Idiopathic Hepatic Uptake of <sup>99m</sup>Tc Methylene Diphosphonate: A Case Report
DP  - 2001 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 32--36
VI  - 29
IP  - 1
4099  - http://tech.snmjournals.org/content/29/1/32.short
4100  - http://tech.snmjournals.org/content/29/1/32.full
SO  - J. Nucl. Med. Technol.2001 Mar 01; 29
AB  - Objective:Two sequential 99mTc methylene diphosphonate (MDP) scans were performed on a 42-y-old woman with insulin-dependent diabetes mellitus, chronic right pyelonephritis and anemia. The initial scan showed reduced skeletal uptake with intense and diffuse hepatic uptake. Because these findings were similar to those seen when excessive hydrolyzed-reduced 99mTc colloids are present in the radiopharmaceutical, the scan was repeated after an adequate time delay. Increased skeletal uptake was evident in the second scan, but the hepatic uptake persisted. Although there are numerous causes of soft tissue activity on 99mTc MDP bone scans, the responsible pathologic entity is not always clear. This study reviews several possible reasons for such uptake, although the exact mechanism in this case remains conjectural.