RT Journal Article SR Electronic T1 The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 22 OP 29 DO 10.2967/jnumed.113.129593 VO 45 IS 1 A1 Ajay Kumar A1 Harry T. Chugani YR 2017 UL http://tech.snmjournals.org/content/45/1/22.abstract AB PET and SPECT can play an important role in the evaluation of various epileptic syndromes, particularly those with unknown causes, by revealing various underlying abnormalities that may not be fully appreciated from MR imaging studies. In some cases, PET and SPECT provide crucial data that guide surgical resections of the epileptogenic zone for medically refractory epilepsy. In other cases, these neuroimaging modalities preclude a surgical option and can guide genetic studies. Longitudinal PET and SPECT studies may increase our understanding of the etiopathogenesis of epilepsy syndromes and provide a clearer picture of the natural history of neurologic progression.