PT - JOURNAL ARTICLE AU - Kulshrestha, Randeep Kumar AU - Vinjamuri, Sobhan AU - England, Andrew AU - Nightingale, Julie AU - Hogg, Peter TI - The Role of <sup>18</sup>F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer AID - 10.2967/jnmt.116.176859 DP - 2016 Dec 01 TA - Journal of Nuclear Medicine Technology PG - 217--222 VI - 44 IP - 4 4099 - http://tech.snmjournals.org/content/44/4/217.short 4100 - http://tech.snmjournals.org/content/44/4/217.full SO - J. Nucl. Med. Technol.2016 Dec 01; 44 AB - We describe the role of 18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. 18F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of 18F-NaF. The performance of 18F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of 18F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of 18F-NaF PET/CT imaging are outlined.