TY - JOUR T1 - The Role of <sup>18</sup>F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 217 LP - 222 DO - 10.2967/jnmt.116.176859 VL - 44 IS - 4 AU - Randeep Kumar Kulshrestha AU - Sobhan Vinjamuri AU - Andrew England AU - Julie Nightingale AU - Peter Hogg Y1 - 2016/12/01 UR - http://tech.snmjournals.org/content/44/4/217.abstract N2 - We describe the role of 18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. 18F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of 18F-NaF. The performance of 18F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of 18F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of 18F-NaF PET/CT imaging are outlined. ER -