@article {Kulshrestha217, author = {Randeep Kumar Kulshrestha and Sobhan Vinjamuri and Andrew England and Julie Nightingale and Peter Hogg}, title = {The Role of 18F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer}, volume = {44}, number = {4}, pages = {217--222}, year = {2016}, doi = {10.2967/jnmt.116.176859}, publisher = {Society of Nuclear Medicine}, abstract = {We describe the role of 18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. 18F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of 18F-NaF. The performance of 18F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of 18F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of 18F-NaF PET/CT imaging are outlined.}, issn = {0091-4916}, URL = {https://tech.snmjournals.org/content/44/4/217}, eprint = {https://tech.snmjournals.org/content/44/4/217.full.pdf}, journal = {Journal of Nuclear Medicine Technology} }